Smad proteins

Smad proteins
Intracellular proteins that mediate signalling from receptors for extracellular TGF b -related factors. Smad2 is essential for embryonic mesoderm formation and establishment of anterior-posterior patterning. Smad4 is important in gastrulation. Smads1 and 5 are activated (serine/threonine phosphorylated) by BMP receptors, Smad2 and 3 by activin and TGF b receptors. Smads activated by occupied receptors then form complexes with Smad4/DPC4 and move into the nucleus where they regulate gene expression. Interact with FAST2.

Dictionary of molecular biology. 2004.

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